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Without L-carnitine, these dietary fats cannot enter the mitochondrial matrix to undergo beta-oxidation, the biochemical process that breaks down fats to generate adenosine triphosphate (ATP), the universal energy currency of the human body

Obesity is not merely a cosmetic concern or a failure of willpower

doi:10.1016/s0006-3223(97)00277-1

Very recently, a systematic review of controlled trials including 25 studies evaluated the effectiveness of physical activity interventions in patients with PWS and confirmed that both total volume of physical activity and physical exercise-related energy expenditure were lower in patients with PWS compared to patients with non-syndromic obesity [50]